Influence of alpha-adrenoceptor blockade on antigen- and propranolol-induced bronchoconstriction in guinea-pigs in vivo

被引：1

作者：

Ishiura, Y ^{[1
]}

Fujimura, M ^{[1
]}

Myou, S ^{[1
]}

Amemiya, T ^{[1
]}

Nobata, K ^{[1
]}

Liu, Q ^{[1
]}

Yamamori, C ^{[1
]}

机构：

[1] Kanazawa Univ, Sch Med, Dept Internal Med 3, Kanazawa, Ishikawa 920, Japan

来源：

JOURNAL OF AUTONOMIC PHARMACOLOGY | 2000年 / 20卷 / 01期

关键词：

D O I：

10.1046/j.1365-2680.2000.00152.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1 Beta-adrenoceptor antagonists, such as propranolol, can provoke severe bronchoconstriction only in asthmatic subjects. Recently, we developed a guinea-pig model of propranolol-induced bronchoconstriction (PIB) and the purpose of this study was to investigate the role of alpha-adrenergic nerve pathways in this reaction. 2 Phentolamine administered after an antigen challenge did not inhibit PIE; however, its administration before the antigen challenge significantly inhibited the antigen-induced bronchoconstriction and also bronchoconstriction induced by methacholine inhalation. 3 We conclude that the alpha-adrenergic nerve system is not involved in the development of PIE following allergic reaction in our guinea-pig model.

引用

页码：23 / 30

页数：8

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