Polymer Based Extracellular Matrix Mimetics For 3D Cell Culture

Electrospinning method is one of the advanced manufacturing technologies that widely used in biomedical applications. Especially the aim of tissue engineering is to fabricate naturally or synthetic support material (scaffold) for a tissue which is studied to provide suitable environment for cells. The aim of the project is producing poly (L-lactide-co-epsilon-caprolactone) (PLLCL) nanofibers as a scaffold by using electrospinning method in order to three dimensional (3D) cell cultures studies. Optimization studies were made in order to obtain homogeneous fibers and suitable pore size. The obtained fibers diameter decreases by increasing flow rate and voltage. By scanning electron microscopy (SEM) morphological structures of fibers examined that exhibiting nearly perfect condtions for scaffold.