Management of Eosinophilic Esophagitis Based on Pathophysiological Evidence

被引:5
|
作者
van Rhijn, Bram D. [1 ]
Bredenoord, Albert J. [2 ]
机构
[1] Univ Med Ctr, Dept Dermatol & Allergol, Huispostnummer L 00-509,POB 85500, NL-3508 GA Utrecht, Netherlands
[2] Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands
关键词
eosinophilic esophagitis; epithelial barrier; etiology; PPI-REE; treatment; GASTROESOPHAGEAL-REFLUX DISEASE; THYMIC STROMAL LYMPHOPOIETIN; TOPICAL STEROID-THERAPY; ENDOSCOPIC REFERENCE SCORE; CRTH2 ANTAGONIST OC000459; HIGH-RESOLUTION MANOMETRY; 6-FOOD ELIMINATION DIET; MUCOSAL INTEGRITY; ADULT PATIENTS; SWALLOWED FLUTICASONE;
D O I
10.1097/MCG.0000000000000879
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Over the past decades eosinophilic esophagitis (EoE) has been increasingly diagnosed, and significant progress has been made in our understanding of its pathophysiology. As EoE cannot be cured yet, treatment goals are suppression of disease activity and symptoms as well as the prevention of progression to a more severe disease phenotype. Disease-modifying treatment options can be divided into dietary therapy and immunosuppressive medications, of which topical steroids have been most investigated, yet are still prescribed off-label. In this review, we will summarize recent advances in our understanding of EoE and discuss the mechanisms of action of current treatment options, with emphasis on the role of the esophageal epithelial barrier and the effects of proton-pump inhibitors in the management of patients with EoE.
引用
收藏
页码:659 / 668
页数:10
相关论文
共 50 条
  • [1] The Management of Eosinophilic Esophagitis
    Greenhawt, Matthew
    Aceves, Seema S.
    Spergel, Jonathan M.
    Rothenberg, Marc E.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2013, 1 (04): : 332 - 340
  • [2] Eosinophilic Esophagitis: An Evidence-Based Approach to Therapy
    Gonzalez-Cervera, J.
    Lucendo, A. J.
    [J]. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 2016, 26 (01) : 8 - 18
  • [3] Eosinophilic Esophagitis: Diagnosis and Management
    Lieberman, Jay A.
    Chehade, Mirna
    [J]. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2012, 32 (01) : 67 - +
  • [4] Pharmacologic Management of Eosinophilic Esophagitis
    Falk, Gary W.
    Pesek, Robbie
    [J]. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2024, 44 (02) : 245 - 264
  • [5] Diagnosis and Management of Eosinophilic Esophagitis
    Wilson, Jeffrey M.
    McGowan, Emily C.
    [J]. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2018, 38 (01) : 125 - +
  • [6] Diagnosis and management of eosinophilic esophagitis
    Gupta, Milli
    Grinman, Michelle
    [J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 2024, 196 (04) : E121 - E128
  • [7] Practical Management of Eosinophilic Esophagitis
    Davis, Carla M.
    [J]. PEDIATRIC ANNALS, 2013, 42 (07): : 128 - 134
  • [8] Management of Refractory Eosinophilic Esophagitis
    Mukkada, Vincent A.
    Furuta, Glenn T.
    [J]. DIGESTIVE DISEASES, 2014, 32 (1-2) : 134 - 138
  • [9] Dietary Management of Eosinophilic Esophagitis
    Lucendo, Alfredo
    Groetch, Marion
    Gonsalves, Nirmala
    [J]. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2024, 44 (02) : 223 - 244
  • [10] Diagnosis and management of eosinophilic esophagitis
    Jesus Ballart, Maria
    Monrroy, Hugo
    Iruretagoyena, Mirentxu
    Parada, Alejandra
    Torres, Javiera
    Espino, Alberto
    [J]. REVISTA MEDICA DE CHILE, 2020, 148 (06) : 831 - 841