Rhodium-Catalyzed Dehydrogenative Cycloisomerization of Dienylcyclopropane to Highly Substituted Toluene

被引：2
|
作者：
Nie, Wo [1 ]
Shen, Shichao [1 ]
Ma, Cheng [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 11期
基金：
中国国家自然科学基金;
关键词：
METAL; CYCLOAROMATIZATION; CYCLOPROPANES; REARRANGEMENT; CYCLOADDITIONS; DERIVATIVES; ENEDIYNES; RINGS;
D O I：
10.1021/acs.orglett.1c01265
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rhodium-catalyzed dehydrogenative cycloisomerization of dienylcyclopropane compounds is reported, which provides a straightforward approach to a variety of highly substituted toluene derivatives in 67-85% yields. The dienylcyclopropaneimides are produced by a single-step formal three-component olefination procedure. Preliminary mechanistic studies indicated that an electron-withdrawing group as R plays a critical role in completing this transformation.
引用
收藏
页码：4337 / 4341
页数：5
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