Novel antifungals based on 4-substituted imidazole: Solid-phase synthesis of substituted aryl sulfonamides towards optimization of in vitro activity

被引：24
|
作者：
Saha, AK [1 ]
Liu, L
Marichal, P
Odds, F
机构：
[1] Janssen Res Fdn, Drug Discovery, Spring House, PA 19477 USA
[2] Janssen Res Fdn, Drug Discovery, B-2340 Beerse, Belgium
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 24期
关键词：
D O I：
10.1016/S0960-894X(00)00551-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The in vitro activity of novel 4-substituted imidazole antifungals was optimized by solid-phase chemistry and parallel synthesis. Potent yeast-selective as well as broad-spectrum antifungal compounds (32 and 20) were discovered. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2735 / 2739
页数：5
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