Relationship between cerebral injury and inflammatory responses in patients undergoing cardiac surgery with cardiopulmonary bypass

This study was performed to evaluate whether cytokines, adhesion molecules, ghrelin and S-100B are useful markers, in predicting the cerebral infarction after cardiac surgery with cardioplumoniary bypass (CPB). The patients (n = 20) were classified into two groups; group A (n = 4) showed postoperative organized cerebral damage. while group B (n = 16) consisted of patients without occurrence of postoperative strokes. Before CPB. serum levels of S-100B in both group A and B were low (<0.5 ng/mL). while, ghrelin concentrations in group A (all patients had history of strokes) were much higher than those in group B. After CPB- when serum levels of S-100B in group A at 24 It were higher than those in group B. ghrefin in group A at same time point Showed high levels in comparison to group B. At 12 and 24 It after CPB. levels of tumor necrosis factor (TNF)-alpha. interieukin-10 and Soluble TNF-receptor I in group A were signiticantly higher than those in group B. In conclusion. it is considered that ghrelin as well as S-100B can be a useful marker for the prediction of stoke after CPB. Increase of TNF-alpha.. interleukin-10 and Soluble TNF-recepior I after CPB may be involved in the pathogenesis of stroke after CPB. (C) 2004 Elsevier Ltd. All rights reserved.