Oxaliplatin exerts potent in vitro cytotoxicity in colorectal and pancreatic cancer cell lines and liver metastases

被引：0
|
作者：
Kornmann, M [1 ]
Fakler, H [1 ]
Butzer, U [1 ]
Beger, HG [1 ]
Link, KH [1 ]
机构：
[1] Univ Ulm, Dept Gen Surg, D-89075 Ulm, Germany
来源：
ANTICANCER RESEARCH | 2000年 / 20卷 / 5A期
关键词：
hepatic arterial infusion; regional chemotherapy; liver metastases; colon cancer; pancreatic cancer;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background. Oxaliplatin displays potent activity in advanced colorectal cancer. The aim of this study was to estimate the potential efficacy of oxaliplatin for hepatic arterial infusion (HAI) chemotherapy. Materials and Methods. The antiproliferative effects of oxaliplatin in human HT29 and NMG64/84 colon and COLO-357 MIA PaCa-2 and PMH2/89 pancreatic cancel cell lines and in fresh liver metastases from patients with colorectal and pancreatic cancer were investigated using the human tumor colony forming assay. Results. Oxaliplatin significantly inhibited the colony formation in all cell lines in a concentration - and time - dependent manner. All liver armors displayed a significant concentration - dependent inhibition of colony formation after exposure to oxaliplatin for 2 hours. The IC50 of oxaliplatin of 9 of the 10 tumors was < 10 <mu>g/ml. Conclusion: Oxaliplatin is suitable for HAI therapy phase II studies. Due to the low IC50 values of most tumors we suggest that patients with colorectal or pancreatic liver metastases may benefit from HAI with oxaliplatin.
引用
收藏
页码：3259 / 3264
页数：6
相关论文
共 50 条
  • [1] Connexin 43 enhances oxaliplatin cytotoxicity in colorectal cancer cell lines
    Wang, S. Q.
    Zhang, S. W.
    Zhang, C. Z.
    Zhao, Z. Y.
    Wang, Y. J.
    [J]. CELLULAR AND MOLECULAR BIOLOGY, 2017, 63 (04) : 53 - 58
  • [2] Autophagy inhibition potentiates oxaliplatin cytotoxicity in hypoxic colon cancer cell lines in vitro and in vivo
    Selvakumaran, Muthu
    Vasilevskaya, Irina
    Amaravadi, Ravi
    O'Dwyer, Peter
    [J]. CANCER RESEARCH, 2009, 69
  • [3] Comparison of Different Colorectal Cancer With Liver Metastases Models Using Six Colorectal Cancer Cell Lines
    Xu, Yuting
    Zhang, Lin
    Wang, Qingling
    Zheng, Maojin
    [J]. PATHOLOGY & ONCOLOGY RESEARCH, 2020, 26 (04) : 2177 - 2183
  • [4] Functional analysis of the gene expression profiles of colorectal cancer cell lines in relation to oxaliplatin and cisplatin cytotoxicity
    Meynard, Delphine
    Le Morvan, Valtrie
    Bonnet, Jacques
    Robert, Jacques
    [J]. ONCOLOGY REPORTS, 2007, 17 (05) : 1213 - 1221
  • [5] Oxaliplatin as neoadjuvant therapy for advanced colorectal cancer with unresectable liver metastases
    Kukic, Biljana P.
    Jovanvic, Dusan M.
    Jankovic, Ljubomir O.
    Nikolic, Ivan V.
    Bogdanovic, Bogdan D.
    [J]. ANNALS OF ONCOLOGY, 2004, 15 : 101 - 101
  • [6] Copper transporter 1 in human colorectal cancer cell lines: Effects of endogenous and modified expression on oxaliplatin cytotoxicity
    Cui, Haigang
    Zhang, Anna J.
    McKeage, Mark J.
    Nott, Louise M.
    Geraghty, Dominic
    Guven, Nuri
    Liu, Johnson J.
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2017, 177 : 249 - 258
  • [7] HDAC inhibitors, MS275 and SBHA, enhances cytotoxicity induced by oxaliplatin in the colorectal cancer cell lines
    Flis, Sylwia
    Gnyszka, Agnieszka
    Splawinski, Jacek
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 387 (02) : 336 - 341
  • [8] In Vitro Schedule-Dependent Interaction Between Melphalan and Oxaliplatin in Human Colorectal Cancer Cell Lines
    van Iersel, Liselot B. J.
    Koudijs, Tamara M.
    Hoekman, Ellen J.
    Janssen-van Rhijn, Connie M.
    Vahrmeijer, Alexander L.
    Nortier, Johan W. R.
    van de Velde, Cornelis J. H.
    Gelderblom, Hans
    Kuppen, Peter J. K.
    [J]. JOURNAL OF SURGICAL RESEARCH, 2011, 167 (02) : 273 - 278
  • [9] Synthesis and in vitro cytotoxicity of benzoxazole-based PPARα/γ antagonists in colorectal cancer cell lines
    Moreno-Rodriguez, Nazaret
    Laghezza, Antonio
    Cerchia, Carmen
    Sokolova, Darina V.
    Spirina, Tatiana S.
    De Filippis, Barbara
    Romanelli, Virgilio
    Recio, Rocio
    Fernandez, Inmaculada
    Loiodice, Fulvio
    Pokrovsky, Vadim S.
    Ammazzalorso, Alessandra
    Lavecchia, Antonio
    [J]. ARCHIV DER PHARMAZIE, 2024, 357 (09)
  • [10] Different mechanism of Oxaliplatin resistance in human colorectal cancer cell lines
    Yamano, Tomoki
    Kubo, Shuji
    Yano, Aya
    Tomita, Naohiro
    [J]. CANCER RESEARCH, 2015, 75
12345