Biochemical and Morphological Changes in White Rats After Intragastric Injecton of a Synthetic Nanobiocomposite Based on Silver Nanoparticles and Arabinogalactan

被引：1
|
作者：
Novikov, M. A. [1 ]
Titov, E. A. [1 ]
Sosedova, L. M. [1 ]
Ostroukhova, L. A. [2 ]
Trofimova, N. N. [2 ]
Babkin, V. A. [2 ]
机构：
[1] Russian Acad Med Sci, Res Inst Occupat Med & Human Ecol, Siberian Branch, Angarsk 665827, Russia
[2] Russian Acad Sci, Favorsky Inst Chem, Siberian Branch, Irkutsk 664033, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 48卷 / 06期
关键词：
nanocomposite; arabinogalactan; Ag nanoparticles; experimental studies; subacute injection; white rats; organ tissue morphology; NANOCOMPOSITES;
D O I：
10.1007/s11094-014-1116-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Results from the synthesis and biological testing of a new nanobiocomposite containing silver (Ag) nanoparticles encapsulated in the natural biologically active polymer arabinogalactan were presented. The physicochemical properties of the water-soluble Ag-containing polymeric nanocomposite were described. It was found that the new nanocomposite upon intragastric injection to white rats activated the antioxidant system, caused slight changes in brain and liver tissues, and produced biochemical shifts characteristic of compensatory-adaptive stress mechanisms.
引用
收藏
页码：387 / 390
页数：4
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