Selective Electrochemical Determination of Paracetamol Using Nanostrutured Film of Functionalized Thiadiazole Modified Electrode

This paper describes the selective electrochemical determination of paracetamol (PA) in the presence of important interferent, ascorbic acid (AA) using an ultrathin electropolymerized film of 5-amino-1,3,4-thiadiazole-2-thiol (p-ATT) modified glassy carbon (GC) electrode in 0.20 M phosphate buffer solution (pH 7.20). Bare GC electrode failed to resolve the voltammetric signals of AA and PA in a mixture. On the other hand, the p-ATT modified electrode not only separated the voltammetric signals of AA and PA but also enhanced their peak currents. We achieved the lowest detection lit-nit of 0.34 nM (S/N=3) for PA at p-ATT modified electrode.