Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving

Objective: Functional magnetic resonance Imaging (MRI) was used to test whether brain activation was detectable in regions previously associated with cocaine cue-induced craving. Method: Blood oxygenation level dependent (BOLD) functional activation was measured during presentation of audiovisual stimuli containing alternating intervals of drug-related and neutral scenes to six male subjects with a history of crack cocaine use and six male comparison subjects. Results: Significant activation was detected in the anterior cingulate and left dorsolateral prefrontal cortex in the cocaine-using group. In addition, a correlation between self-reported levels of craving and activation in these regions was found. Conclusions: These results suggest that Junctional MRI may be a useful tool to study the neurobiological basis of cue-induced craving.