Circulating Tumor DNA Analysis Depicts Potential Mechanisms of Resistance to BRAF-Targeted Therapies in BRAF plus Non-Small Cell Lung Cancer

被引:4
|
作者
Ortiz-Cuaran, S. [1 ]
Mezquita, L. [2 ]
Swalduz, A. [3 ]
Aldea, M. [2 ]
Mazieres, J. [4 ]
Jovelet, C. [5 ]
Flores, W. R. Chumbi [6 ]
Lacroix, L. [7 ]
Loriot, Y. [2 ]
Friboulet, L. [2 ]
Westeel, V. [8 ]
Ngocamus, M. [9 ]
Pradines, A. [10 ]
Tissot, C. [11 ]
Duchene, C. Clement [12 ]
Raynaud, C. [13 ]
Quantin, X. [14 ]
Gervais, R. [15 ]
Brain, E. [16 ]
Monnet, I. [17 ]
Leprieur, E. Giroux [18 ]
Avrillon, V. [19 ]
Oukhatar, C. Mahier-Ait [20 ]
Hoog-Labouret, N. [21 ]
De Kievit, F. [22 ]
Howarth, K. [22 ]
Guichou, J. [23 ]
Morris, C. [22 ]
Green, E. [22 ]
Perol, M. [24 ]
Besse, B. [25 ]
Blay, J. [3 ]
Saintigny, P. [1 ]
Planchard, D. [26 ]
机构
[1] Ctr Leon Berard, Canc Res Ctr Lyon, Translat Res, Lyon, France
[2] Gustave Roussy, Med Oncol Dept, Villejuif, France
[3] Ctr Leon Berard, Med Oncol, Lyon, France
[4] CHU Toulouse, Toulouse, France
[5] Gustave Roussy, Genom Dept, Villejuif, France
[6] Hosp Civils Lyon, Serv Pneumol, Lyon, France
[7] Gustave Roussy, Med Biol & Pathol, Villejuif, France
[8] Univ Hosp Besancon, Reg Inst Canc, Besancon, France
[9] Gustave Roussy, Villejuif, France
[10] Inst Claudius Regaud, Biol Med Oncol, Toulouse, France
[11] Univ Hosp St Etienne, St Etienne, France
[12] Hop Brabois, Vandoeuvre Les Nancy, France
[13] Inst Mutualiste Montsouris, Paris, France
[14] Univ Hosp Montpellier, Montpellier, France
[15] Ctr Francois Baclesse, Caen, France
[16] Hop Rene Huguenin, St Cloud, France
[17] Chi Creteil, Pneumol, Creteil, France
[18] AP HP, Ambroise Pare Ctr, Paris, France
[19] Ctr Leon Berard, Lyon, France
[20] Unicancer, Paris, France
[21] Inst Natl Canc, Boulogne, France
[22] Inivata Ltd, Cambridge, England
[23] Univ Montpellier, CNRS, INSERM, Cbs, Montpellier, France
[24] Ctr Leon Berard, Dept Thorac Oncol, Lyon, France
[25] Inst Gustave Roussy, Med Oncol, Thorac Grp, Villejuif, France
[26] Gustave Roussy, Thorac Grp, Dept Med Oncol, Villejuif, France
关键词
braf; resistance; circulating-tumor DNA;
D O I
10.1016/j.jtho.2019.08.678
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
MA21.07
引用
下载
收藏
页码:S337 / S337
页数:1
相关论文
共 50 条
  • [1] Circulating Tumor DNA Genomics Reveal Potential Mechanisms of Resistance to BRAF-Targeted Therapies in Patients with BRAF-Mutant Metastatic Non-Small Cell Lung Cancer
    Ortiz-Cuaran, Sandra
    Mezquita, Laura
    Swalduz, Aurelie
    Aldea, Mihalea
    Mazieres, Julien
    Leonce, Camille
    Jovelet, Cecile
    Pradines, Anne
    Avrillon, Virginie
    Flores, Washington R. Chumbi
    Lacroix, Ludovic
    Loriot, Yohann
    Westeel, Virginie
    Ngo-Camus, Maud
    Tissot, Claire
    Raynaud, Christine
    Gervais, Radj
    Brain, Etienne
    Monnet, Isabelle
    Leprieur, Etienne Giroux
    Caramella, Caroline
    Oukhatar, Celine Mahier-Ait
    Hoog-Labouret, Natalie
    de Kievit, Frank
    Howarth, Karen
    Morris, Clive
    Green, Emma
    Friboulet, Luc
    Chabaud, Sylvie
    Guichou, Jean-Francois
    Perol, Maurice
    Besse, Benjamin
    Blay, Jean-Yves
    Saintigny, Pierre
    Planchard, David
    CLINICAL CANCER RESEARCH, 2020, 26 (23) : 6242 - 6253
  • [2] BRAF Mutations and Resistance of Non-Small Cell Lung Cancer to BRAF-Targeted Therapies Using Liquid Biopsy
    Li, Ming
    Zhang, Xiaoying
    ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING, 2021, 8 (02) : 110 - 111
  • [3] Circulating tumour DNA (ctDNA) analysis depicts mechanisms of resistance and tumour response to BRAF inhibitors in BRAF-mutant non-small cell lung cancer (NSCLC)
    Ortiz-Cuaran, S.
    Mezquita, L.
    Swalduz, A.
    Aldea, M.
    Mazieres, J.
    Jovelet, C.
    Lacroix, L.
    Pradines, A.
    Avrillon, V.
    Ouhatar, C. -MahierAit
    Hoog-Labouret, N.
    Howarth, K.
    Guichou, J-F.
    Morris, C.
    Green, E.
    Perol, M.
    Besse, B.
    Blay, J-Y.
    Saintigny, P.
    Planchard, D.
    ANNALS OF ONCOLOGY, 2019, 30 : 641 - 641
  • [4] Advances in BRAF-targeted therapies for non-small cell lung cancer: the promise of encorafenib and binimetinib
    Fareed, Areeba
    Amir, Nabiha
    Ajaz, Humna
    Sohail, Afra
    Vaid, Rayyan
    Farhat, Solay
    INTERNATIONAL JOURNAL OF SURGERY, 2024, 110 (04) : 1891 - 1893
  • [5] Integrative analysis of resistance to BRAF-targeted therapies in lung adenocarcinomas
    Ortiz-Cuaran, Sandra
    Mazieres, Julien
    Swalduz, Aurelie
    Flores, Washington Rene Chumbi
    Loriot, Yohan
    Westeel, Virginie
    Pradines, Anne
    Tissot, Claire
    Duchene, Christelle Clement
    Raynaud, Christine
    Quantin, Xavier
    Gervais, Radj
    Brain, Etienne
    Monnet, Isabelle
    Leprieur, Etienne Giroux
    Neymarc, Severine
    Avrillon, Virginie
    Marteau, Solene
    Martinez, Severine
    Clapisson, Gilles
    Girerd-Chambaz, Nathalie
    Mahier, Celine
    Hoog-Labouret, Nathalie
    de Kievit, Frank
    Howarth, Karen
    Green, Emma
    Morris, Clive
    Perol, Maurice
    Blay, Jean-Yves
    Saintingy, Pierre
    CANCER RESEARCH, 2018, 78 (13)
  • [6] Circulating tumour DNA sequencing reveal mechanisms of resistance to BRAF-targeted therapies in BRAF-mutated gastrointestinal stromal tumour
    Ceruso, Mariella Spalato
    Toulmonde, Maud
    Blouin, Laura
    Italiano, Antoine
    EUROPEAN JOURNAL OF CANCER, 2023, 179 : 25 - 27
  • [7] Resistance mechanisms to BRAF inhibition identified by single circulating tumor cell and cell-free tumor DNA molecular profiling in BRAF-mutant non-small cell lung cancer.
    Mezquita, Laura
    Oulhen, Marianne
    Aberlenc, Agathe
    Deloger, Marc
    Honore, Aurelie
    Garonzi, Marianna
    Buson, Genny
    Forcato, Claudio
    Lecluse, Yann
    Aldea, Mihaela
    NgoCamus, Maud
    Nicotra, Claudio
    Howarth, Karen
    Lacroix, Ludovic
    Friboulet, Luc
    Besse, Benjamin
    Manaresi, Nicolo
    Planchard, David
    Farace, Francoise
    CANCER RESEARCH, 2021, 81 (13)
  • [8] BRAF mutant non-small cell lung cancer and treatment with BRAF inhibitors
    Miguel Sanchez-Torres, Jose
    Viteri, Santiago
    Angel Molina, Miguel
    Rosell, Rafael
    TRANSLATIONAL LUNG CANCER RESEARCH, 2013, 2 (03) : 244 - 250
  • [9] BRAF mutations in non-small cell lung cancer
    Luk, Peter P.
    Yu, Bing
    Ng, Chiu Chin
    Mercorella, Belinda
    Selinger, Christina
    Lum, Trina
    Kao, Steven
    O'Toole, Sandra A.
    Cooper, Wendy A.
    TRANSLATIONAL LUNG CANCER RESEARCH, 2015, 4 (02) : 142 - 148
  • [10] BRAF Inhibitors in Non-Small Cell Lung Cancer
    Sforza, Vincenzo
    Palumbo, Giuliano
    Cascetta, Priscilla
    Carillio, Guido
    Manzo, Anna
    Montanino, Agnese
    Sandomenico, Claudia
    Costanzo, Raffaele
    Esposito, Giovanna
    Laudato, Francesca
    Damiano, Simona
    Forte, Cira Antonietta
    Frosini, Giulia
    Farese, Stefano
    Piccirillo, Maria Carmela
    Pascarella, Giacomo
    Normanno, Nicola
    Morabito, Alessandro
    CANCERS, 2022, 14 (19)