SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF 4-THIAZOLIDINONE DERIVATIVES INCORPORATING BENZOFURAN MOIETY

5-Bromo-1-benzofuran-2-yl(substituted phenyl) methanones (2a-e) were prepared by the reaction of 2-bromo-1-(phenyl) ethanones and 5-bromosalicylaldehyde in dimethylformamide in the presence of anhydrous potassium carbonate to maintain basic condition. Condensation of (2a-e) with hydrazine hydrate gave (1Z) [(6-bromo-1-benzofuran-2-yl) (phenyl) methylidene] hydrazines (3a-e). The compounds (3a-e) treated with benzaldehyde to give formaldehyde [(Z)-(6-bromo-1-benzofuran-2-yl) (phenyl) methylidene] hydrazones (4a-e), further these compounds underwent cyclisation upon treatment with thioglycollic acid to furnish 3-{[(3-(E)- (6-bromo-1-benzofuran-2-yl) (phenyl) methylidene] amino}-1,3-thiazolidin-4-ones (5a-e) respectively. The structures of all synthesized compounds were established on the basis of analytical and spectral studies. These compounds were evaluated for their antimicrobial and antitubercular activities.