Facile preparation of 3-amino-4-(arylamino)-1H-isochromen-1-ones by a new multicomponent reaction

被引：24
|
作者：
Opatz, T [1 ]
Ferenc, D [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55138 Mainz, Germany
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 05期
关键词：
multicomponent reactions; heterocycles; cyclization; amines; strecker reaction;
D O I：
10.1002/ejoc.200400685
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reactions between 2-formylbenzoic acid, various anilines and HCN result in the formation of 3-amino-4-(arylamino)-1H-isochromen-1-ones in high yield. The mechanism of this three-component condensation involves the intermediate formation of an alpha-aminonitrile and subsequent cyclizationthrough nucleophilic attack of the ortho-carboxylate at the nitrile carbon. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).
引用
收藏
页码：817 / 821
页数：5
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