First-trimester antihistamine exposure and risk of spontaneous abortion or preterm birth

被引:7
|
作者
Aldridge, Tiara D. [1 ,2 ,3 ]
Hartmann, Katherine E. [1 ,2 ,3 ]
Michels, Kara A. [1 ,2 ,3 ]
Edwards, Digna R. Velez [1 ,2 ,3 ,4 ]
机构
[1] Vanderbilt Epidemiol Ctr Nashville, Nashville, TN USA
[2] Vanderbilt Univ, Inst Med & Publ Hlth Nashville, Nashville, TN USA
[3] Vanderbilt Univ, Dept Obstet & Gynecol Nashville, Nashville, TN USA
[4] Vanderbilt Univ Nashville, Ctr Human Genet Res, Nashville, TN USA
关键词
pregnancy; pharmacoepidemiology; histamine antagonists; prospective studies; HISTAMINE; PREGNANCY; RANITIDINE; RECEPTORS; UTERUS; MOUSE; CELLS;
D O I
10.1002/pds.3637
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Purpose We tested whether antihistamine exposure during early pregnancy is associated with spontaneous abortion (SAB) or preterm birth (PTB). Methods Women were enrolled in Right from the Start (2004-2010), a prospective pregnancy cohort. Data about first-trimester antihistamine use were obtained from screening and first-trimester interviews. Self-reported outcomes included SAB and PTB and were verified by medical records. Cox proportional hazards models were used to test for an association between antihistamine use and each outcome, both performed adjusting for confounders. Results Among the 2685 pregnancies analyzed, 14% (n = 377) reported use of antihistamines. Among antihistamine users, 12% (n = 44) experienced SABs, and 6% (n = 21) had PTBs. Antihistamine exposure was not associated with SAB (adjusted hazard ratio [aHR] = 0.88, 95% confidence interval [CI] 0.64, 1.21) or PTB, which was modified by maternal race (aHR = 1.03, 95% CI 0.61, 1.72 among White women and aHR = 0.43, 95% CI 0.14, 1.34 among Black women). Conclusions Despite the biologic plausibility that antihistamine use may influence pregnancy outcomes, we did not detect evidence of an association with SAB or PTB. These data demonstrate the utility of large prospective cohorts for evaluating drug safety in pregnancy when concerns are raised from animal models. Copyright (C) 2014 John Wiley & Sons, Ltd.
引用
收藏
页码:1043 / 1050
页数:8
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