A Nonovershooting Controller with Integral Action for Multi-input Multi-output Drug Dosing Control

被引：1

作者：

Padmanabhan, Regina ^{[1
]}

Meskin, Nader ^{[1
]}

Ionescu, Clara M. ^{[2
]}

Haddad, Wassim M. ^{[3
]}

机构：

[1] Qatar Univ, Dept Elect Engn, Doha, Qatar

[2] Univ Ghent, Dept Elect Energy, Technol Pk 913, B-9052 Ghent, Belgium

[3] Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA

来源：

IFAC PAPERSONLINE | 2018年 / 51卷 / 04期

关键词：

Nonovershooting control; active drug dosing; biomedical control; ANESTHESIA;

D O I：

10.1016/j.ifacol.2018.06.029

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

In this paper, a nonovershooting tracking controller is proposed for the continuous infusion of multiple drugs that have interactive effects. The proposed controller design method exploits the freedom of eigenstructure assignment pertinent to the design of feedback controllers for multi-input, multi-output (MIMO) systems. For drug dosing, a nonovershooting tracking controller restricts the undesirable side effects of drug overdosing. The proposed tracking controller is based on an estimate of the full state using a hybrid extended Kalman filter (EKF) that is used to reconstruct the system states from the measurable system outputs. An integral control action is included in the controller design to achieve robust tracking in the presence of patient parameter uncertainty. Simulation results and performance analysis of the proposed control strategy are also presented using 20 simulated patients. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

引用

页码：60 / 65

页数：6

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