Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients

被引：8

作者：

Scheithauer, Simone ^{[1
]}

Haase, Gerhard

Haeusler, Martin ^{[2
]}

Lemmen, Sebastian ^{[1
]}

Ritter, Klaus ^{[3
]}

Kleines, Michael ^{[3
]}

机构：

[1] Univ Hosp RWTH Aachen, Dept Infect Control & Infect Dis, Aachen, Germany

[2] Univ Hosp RWTH Aachen, Dept Pediat, Aachen, Germany

[3] Univ Hosp RWTH Aachen, Dept Med Microbiol, Div Virol, Aachen, Germany

来源：

JOURNAL OF CYSTIC FIBROSIS | 2010年 / 9卷 / 03期

关键词：

Infection; Exacerbation; Emerging viruses; Herpesvirus; VIRAL-INFECTIONS; TRACT INFECTIONS;

D O I：

10.1016/j.jcf.2010.02.002

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Respiratory viruses discovered in the 21st century and human herpes viruses (N=13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75 +/- 2.9/a versus 4.45 +/- 2.1/a; p=0.03) and colonization with Aspergillus fumigatus (RR: 2.6; CI95: 1.8-3.7), Pseudomonas aeruginosa (RR: 1.84; CI95: 1.4-2.4), and Staphylococcus aureus (RR: 1.5; CI95: 1.2-1.9) including MRSA (RR: 4.6; CI95: 1.3-16.6) were associated with virus positivity. Further studies should clarify whether this finding reflects non-specific colonization (human Bocavirus) or reactivation (Epstein-Barr virus) or rather an acceleration of lung tissue inflammation. (C) 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：234 / 236

页数：3

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