Capacitive biosensors for ultra-sensitive assays

被引：34

作者：

Mattiasson, Bo ^{[1
,2
]}

Hedstrom, Martin ^{[1
,2
]}

机构：

[1] CapSenze Biosyst AB, Lund, Sweden

[2] Lund Univ, Dept Biotechnol, Lund, Sweden

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2016年 / 79卷

基金：

瑞典研究理事会;

关键词：

Capacitive transduction; Ultra-sensitive; Affinity biosensor; Gold surface; Electropolymerization; MIP; Microcontact imprinting; ESCHERICHIA-COLI; IMMUNOSENSOR; IMMOBILIZATION; ELECTRODES; CELL;

D O I：

10.1016/j.trac.2015.10.016

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Capacitive binding assays have long been considered highly sensitive. The underlying method in such assays includes sending short potential pulses and then registering the current. However, with the introduction of current pulses and registration of potential responses, the stability improved significantly, leading to assays of extreme sensitivities. The new assaying technology has been applied in a range of affinity binding assays, from immunoassays via DNA base pairing to the use of molecularly imprinted polymers (MIPs). Overall, very good sensitivities have been recorded, and the MIPs exhibit high stability and reusability. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：233 / 238

页数：6

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