Objective: This study evaluated the microtensile bond strength (mu TBS) of ion-releasing restorative materials to sound and caries-affected dentin (CAD). Study design: 60 teeth were randomly divided into 2 groups (sound dentin, CAD) and 5 subgroups of 6 samples each: conventional glass ionomer cement (GIC), resinmodified GIC (RMGIC), glass hybrid reinforced GIC (EQ), giomer (BII), and bioactive restorative material (ACT). mu TBS analyses were performed and data were analyzed statistically. Results: The ACT group bonded to sound dentin and the BII group bonded to CAD showed the highest mu TBS (p<0.05). The GIC, RMGIC, and ACT groups, showed significantly lower mu TBS when bonded to CAD compared with sound dentin (p<0.05). However, in the BII group, there were no statistically significant differences between the samples bonded to sound and CAD (p>0.05). All groups except EQ that bonded to sound dentin showed predominantly adhesive failure. Conclusion: The use of the giomer can be recommended due to its more stable bond durability.