Synthesis, Crystal Structure, Thermal Stability and Anti-tumor Activity In Vitro of Bis(tricyclohexyltin) Pimelicarboxylate

Bis(tricyclohexyltin) pimelicarboxylate, [(CH2)(5)(CO2SnCy3)(2)] (1), has been synthesized by the reaction of tricyclohexyltin hydroxide with pimelic acid and characterized by means of IR, H-1 and C-13 NMR, elemental analysis and X-ray diffraction. Complex 1 crystallizes in triclinic space group P (1) over bar with a = 11.569(3), b = 12.0419(2), c = 17.3988(4) angstrom, alpha = 81.4310(10), beta = 79.8270(10), gamma = 69.7060(10)degrees, V = 2227.60(9) angstrom(3), Z = 2, C43H76O4Sn2, M-r = 894.42, D-c = 1.333 g.cm(-3), mu = 1.157 mm(-1), F(000) = 932, GOOF = 1.339, the final R = 0.0452 and wR = 0.1333 for 6709 observed reflections (I> 2 sigma(I)). Complex 1 shows discrete dimeric structures and the tin atoms have a distorted tetrahedral geometry. The 1D chain structure of complex 1 is formed by intermolecular Sn center dot center dot center dot O interactions. Complex 1 displays good thermal stability under 553 K and has selective antibacterial property. Complex 1 is strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460, and is significantly higher than that in the clinical use of carboplatin.