Endothelial progenitor cells-an evolving story

被引：68
|
作者：
Pearson, Jeremy D. [1 ]
机构：
[1] Kings Coll London, Div Cardiovasc, London SE1 9NH, England
来源：
MICROVASCULAR RESEARCH | 2010年 / 79卷 / 03期
关键词：
Endothelium; Monocytes; Stem cells; Progenitor cells; Angiogenesis; MARROW-DERIVED CELLS; EMBRYONIC STEM-CELLS; IN-VITRO MODEL; BONE-MARROW; NEOINTIMAL FORMATION; VASCULAR REPAIR; MOUSE MODEL; DIFFERENTIATION; CONTRIBUTE; BLOOD;
D O I：
10.1016/j.mvr.2009.12.004
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
The first description of endothelial progenitor cells (EPC) in 1997 led rapidly to substantial changes in our understanding of angiogenesis, and within 5 years to the first clinical studies in humans using bone marrow derived EPC to enhance coronary neovascularisation and cardiac function after myocardial ischemia. However, to improve the success of this therapy a clearer understanding of the biology of EPC is needed. This article summarises recent data indicating that most EPC are not, in fact, endothelial progenitors but can be better described as angiogenic monocytes, and explores the implications this has for their future therapeutic use. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：162 / 168
页数：7
相关论文
共 50 条
  • [1] Frontiers in nephrology: The evolving therapeutic applications of endothelial progenitor cells
    Tongers, Joern
    Losordo, Douglas W.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (11): : 2843 - 2852
  • [2] Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept
    Malli, Foteini
    Koutsokera, Angela
    Paraskeva, Efrosini
    Zakynthinos, Epaminondas
    Papagianni, Maria
    Makris, Dimosthenes
    Tsilioni, Irene
    Molyvdas, Paschalis Adam
    Gourgoulianis, Konstantinos I.
    Daniil, Zoe
    [J]. PLOS ONE, 2013, 8 (01):
  • [3] The Long Telling Story of "Endothelial Progenitor Cells": Where Are We at Now?
    Vinci, Maria Cristina
    Carulli, Ermes
    Rurali, Erica
    Rinaldi, Raffaella
    Damiano, Giulia
    Raucci, Angela
    Pompilio, Giulio
    Genovese, Stefano
    [J]. CELLS, 2023, 12 (01)
  • [4] Endothelial progenitor cells
    Khakoo, AY
    Finkel, T
    [J]. ANNUAL REVIEW OF MEDICINE, 2005, 56 : 79 - 101
  • [5] Endothelial progenitor cells
    Rosenzweig, A
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (07): : 581 - 582
  • [6] Endothelial progenitor cells
    Doyle, Brendan
    Metharom, Pat
    Caplice, Noel M.
    [J]. ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH, 2006, 13 (06): : 403 - 410
  • [7] ENDOTHELIAL PROGENITOR CELLS
    Tekeli, S. Ozgur
    Emerk, Kaya
    [J]. MARMARA MEDICAL JOURNAL, 2007, 20 (01): : 59 - 65
  • [8] Endothelial Progenitor Cells for Tissue Engineering and Tissue Regeneration Endothelial Progenitor Cells
    Bischoff, Joyce
    [J]. ADVANCES IN REGENERATIVE MEDICINE: ROLE OF NANOTECHNOLOGY AND ENGINEERING PRINCIPLES, 2010, : 45 - 54
  • [9] Endothelial progenitor cells and endothelial dysfunction
    Hill, JM
    Zalos, G
    Halcox, JP
    Schenke, WH
    Finkel, T
    Quyyumi, AA
    [J]. CIRCULATION, 2002, 106 (19) : T - T
  • [10] Endothelial progenitor cells and endothelial dysfunction
    Hill, JM
    Finkel, T
    Quyyumi, AA
    [J]. VOX SANGUINIS, 2004, 87 : 31 - 37
12345