Aminopyridines: selective Aurora-A inhibitors

被引：8
|
作者：
Vianello, Paola [1 ]
机构：
[1] Nerviano Med Sci SRL, BU Oncol, I-20014 Nerivano, MI, Italy
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2007年 / 17卷 / 02期
关键词：
Aurora-A; Aurora-B; micosis;
D O I：
10.1517/13543776.17.2.255
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Aurora inhibitors have been extensively studied as potential novel anticancer agents. At least four compounds are now under clinical evaluation. Banyu discloses aminopyridines and -pyrazines acting as selective Aurora-A inhibitors. The claimed compounds demonstrated low nanomolar activity in the biochemical assay and exhibit a 200-fold specificity on Aurora-A versus Aurora-B.
引用
收藏
页码：255 / 261
页数：7
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