Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia

被引：1
|
作者：
Luo, Qiong [1 ,2 ,3 ]
Lei, Bin [1 ,2 ]
Liu, Shuguang [1 ,2 ]
Chen, Yaowen [4 ]
Sheng, Wenjie [1 ,2 ]
Lin, Peixin [1 ,2 ]
Li, Wenxia [1 ,2 ]
Zhu, Haili [1 ,2 ]
Shen, Hong [1 ,2 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou 515000, Guangdong, Peoples R China
[2] Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou 515000, Guangdong, Peoples R China
[3] Leiyang Peoples Hosp, Dept Oncol, Leiyang City, Hunan, Peoples R China
[4] Shantou Univ, Cent Lab, Shantou City, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2014年 / 7卷 / 11期
关键词：
Cervical carcinoma; CINI; T-LAK; PDZ-binding kinase; quantitative analysis; ORIGINATED PROTEIN-KINASE; PDZ-BINDING KINASE; CELL LUNG-CANCER; MITOTIC KINASE; TOPK PHOSPHORYLATION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia. Methods: PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical cancer by immunohistochemistry (IHC). Then, the correlation between PBK/TOPK expression and clinicopathological features was quantitatively analyzed by measuring the positive unit (PU). Results: PBK/TOPK expression was significantly greater in cervical cancer than that in high-grade intraepithelial neoplasia and CINI (P < 0.05). Meanwhile, PBK/TOPK expression in high-grade intraepithelial neoplasia was significantly higher compared with that in CINI (P < 0.05). In addition, PBK/TOPK expression in cervical cancer significantly correlated with histological type, differentiation, lymph node metastasis, vaginal and cervical invasion, TNM stage and tumor size (P < 0.05). Conclusion: PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.
引用
收藏
页码：8059 / 8064
页数：6
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