Living cell-based regenerative medicine technologies for periodontal soft tissue augmentation

被引:18
|
作者
McGuire, Michael K. [1 ,2 ,3 ]
Tavelli, Lorenzo [1 ]
Feinberg, Stephen E. [4 ]
Rasperini, Giulio [1 ,5 ]
Zucchelli, Giovanni [1 ,6 ]
Wang, Hom-Lay [1 ]
Giannobile, William, V [1 ,7 ,8 ]
机构
[1] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, 1011 North Univ Ave, Ann Arbor, MI 48109 USA
[2] Univ Texas San Antonio, Dept Periodont, Dent Branch Houston, San Antonio, TX USA
[3] Hlth Sci Ctr, San Antonio, TX USA
[4] Univ Michigan, Dept Oral & Maxillofacial Surg, Ann Arbor, MI 48109 USA
[5] Univ Milan, Dept Biomed Surg & Dent Sci, Fdn IRCCS Ca Granda Policlin, Milan, Italy
[6] Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy
[7] Univ Michigan, Coll Engn, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[8] Univ Michigan, Coll Engn, Biointerfaces Inst, Ann Arbor, MI 48109 USA
关键词
gingival recession; periodontal; regenerative medicine; soft tissue grafting; tissue engineering; tissue scaffolds; DIABETIC FOOT ULCERS; AUTOLOGOUS GINGIVAL FIBROBLASTS; ORAL-MUCOSA EQUIVALENT; DERMAL SUBSTITUTE; ROOT COVERAGE; EFFICACY; DERMAGRAFT; SAFETY; KERATINOCYTES; CONSTRUCT;
D O I
10.1002/JPER.19-0353
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The cultivation of human living cells into scaffolding matrices has progressively gained popularity in the field of periodontal wound healing and regeneration. Living cellular constructs based on fibroblasts, keratinocytes alone or in combination have been developed and used as alternatives to autogenous soft tissue grafts in keratinized tissue augmentation and in root coverage procedures. Their promising advantages include reduced patient morbidity, unlimited graft availability, and comparable esthetics. This manuscript reviews soft tissue augmentation and root coverage procedures using bioengineered living cellular therapy and highlights their expected clinical, esthetic, and patient-related outcomes.
引用
收藏
页码:155 / 164
页数:10
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