Biodegradable Hydrogels for Time-Controlled Release of Tethered Peptides or Proteins

被引：39

作者：

Brandl, Ferdinand ^{[1
]}

Hammer, Nadine ^{[1
]}

Blunk, Torsten ^{[1
]}

Tessmar, Joerg ^{[1
]}

Goepferich, Achim ^{[1
]}

机构：

[1] Univ Regensburg, Dept Pharmaceut Technol, D-93040 Regensburg, Germany

来源：

BIOMACROMOLECULES | 2010年 / 11卷 / 02期

关键词：

SYSTEMS EMPLOYING 1,6-ELIMINATION; DRUG-DELIVERY; MODEL; HYDROLYSIS; DIFFUSION; ACYLATION; DESIGN;

D O I：

10.1021/bm901235g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tethering drug substances to it gel network is all effective way of controlling the release kinetics of hydrogel-based drug delivery systems Here, we report oil in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization of branched poly(ethylene glycol). The gel strength ranged from 1075 to 2435 Pit: the degradation time varied between 24 and 120 h. Fluorescence recovery after photobleaching showed that fluorescently labeled bovine serum albumin (FITC-BSA) was Successfully bound to the gel network during gel formation Within 168 h, the mobility of the tethered molecules gradually increased due to polymer degradation Using FITC-BSA and lysozyme as model proteins, we showed the potential of the developed hydrogels for time-controlled release. The obtained release profiles had a sigmoidal shape and matched the degradation profile very well. protein release wits complete after 96 h

引用

页码：496 / 504

页数：9

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