TNFα gene delivery therapy for solid tumors

Areas covered in this review: We discuss a TNF alpha gene delivery system used to generate high levels of intratumoral TNF alpha, while limiting systemic exposure. The delivery system utilizes a replication-deficient adenoviral vector. When injected intratumorally and activated by external beam radiation, infected cells synthesize and locally secrete large amounts of TNF alpha. What the reader will gain: This review will provide the reader with a thorough understanding of the gene-based TNF alpha delivery system with special emphasis on product characteristics, mechanisms of action, clinical efficacy, safety and tolerability. Take home message: The TNF alpha gene delivery system holds promise as an adjunctive agent for improved local control and increasing resectability rates for many solid tumors. The completion of several ongoing randomized trials will help to better define the role for TNF alpha gene delivery therapy in the treatment of solid tumors.