Testing the glutamate hypothesis of schizophrenia

被引：54
|
作者：
Gordon, Joshua A. [1 ,2 ]
机构：
[1] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY 10027 USA
[2] New York State Psychiat Inst & Hosp, Dept Integrat Neurosci, New York, NY 10032 USA
来源：
NATURE NEUROSCIENCE | 2010年 / 13卷 / 01期
关键词：
RISPERIDONE; DISORDER; MODEL;
D O I：
10.1038/nn0110-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A study in this issue presents a new mouse model that directly tests the glutamate hypothesis of schizophrenia. The study reports that a decrease in NMDA receptor signaling during a particular developmental window in interneurons can induce cellular and behavioral changes similar to those seen in schizophrenia.
引用
收藏
页码：2 / 4
页数：3
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