Pt(II)-catalyzed synthesis of 1,2-dihydropyridines from aziridinyl propargylic esters

被引：43
|
作者：
Motamed, Massoud [1 ]
Bunnelle, Eric M. [1 ]
Singaram, Surendra W. [1 ]
Sarpong, Richmond [1 ]
机构：
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 11期
关键词：
D O I：
10.1021/ol070658i
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pt(II)-catalyzed cycloisomerization of aziridinyl propargylic esters affords 1,2-dihydropyridines with regiodefined installation of substituents. A mild conversion of the 1,2-dihydropyridines to the corresponding substituted pyridines as well as chirality retention from the aziridinyl propargylic ester substrates have been demonstrated.
引用
收藏
页码：2167 / 2170
页数：4
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