Trial to detect significant metrics for drug-induced seizure liability using microelectrode arrays data analysis and primary rodent neurons: From multi-site pilot study of the HESI NeuTox consortium in collaboration with CSAHi and iNCENS

被引：0

作者：

Miyamoto, Norimasa ^{[1
,2
,3
,4
]}

Ojima, Atsuko ^{[1
,2
,3
,5
]}

Inaba, Saori ^{[1
,3
,5
]}

Kitamura, Tetsuo ^{[6
]}

Osada, Tomoharu ^{[2
,7
]}

Yoshinaga, Takashi ^{[1
,2
]}

机构：

[1] Eisai & Co Ltd, Med Dev Ctr, Biopharmaceut Assessments Core Funct Unit, Tsukuba, Ibaraki, Japan

[2] Consortium Safety Assessment iPS Cells CSAHi, Kawasaki, Kanagawa, Japan

[3] iPS Nonclin Expt Nervous Syst iNCENS, Kawasaki, Kanagawa, Japan

[4] HESI, NeuTox Microelectrode Array MEA Subteam, Translat Biomarkers Neurotox NeuTox Comm, Washington, DC USA

[5] TechnoPro R&D Co, TechnoPro Inc, Tsukuba Branch, Tsuchiura, Ibaraki, Japan

[6] LSI Med Corp, Nonclin Res Ctr, Safety Assessment Dept, Kamisu, Japan

[7] LSI Med Corp, Adv Med Business Dev Dept, Tokyo, Japan

来源：

关键词：

D O I：

10.1016/j.vascn.2019.05.077

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

0078

引用

页数：4