A 2-pyridone modified zinc phthalocyanine with three-in-one multiple functions for photodynamic therapy

被引：14
|
作者：
Li, Yanqing [1 ]
Wang, Chongchong [1 ]
Zhou, Lin [1 ]
Wei, Shaohua [1 ,2 ]
机构：
[1] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat, Coll Chem & Mat Sci,Key Lab Appl Photochem, Nanjing 210023, Jiangsu, Peoples R China
[2] Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng 224051, Jiangsu, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 25期
关键词：
OXYGEN; NANOPARTICLES; NANOPLATFORM;
D O I：
10.1039/d1cc00645b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A 2-pyridone modified zinc phthalocyanine (denoted ZnPc-PYR) achieves a one stone for three birds outcome in the photodynamic therapy (PDT) treatment of cancer. ZnPc-PYR can be excited by both 665 and 808 nm light to treat superficial and deep tumors, store and slowly release singlet oxygen (O-1(2)) to improve its utilization and downregulate the HIF-1 (hypoxia-inducible factor 1) expression level to enhance the tumor cell's sensitivity to PDT treatment under hypoxic conditions.
引用
收藏
页码：3127 / 3130
页数：4
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