Prenatal exposure to metals and autism spectrum disorder: Current status and future directions

被引:6
|
作者
Campbell, Kyle A. [1 ]
Hickman, Ruby [1 ]
Fallin, Margaret Daniele [2 ]
Bakulski, Kelly M. [1 ]
机构
[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21218 USA
关键词
Metals; Autism spectrum disorder; Neurodevelopment; Chemical; ENVIRONMENTAL RISK-FACTORS; NEUROTOXICITY; BIOMARKERS; MIXTURES; INCREASE; COHORT;
D O I
10.1016/j.cotox.2021.04.001
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with genetic and environmental contributors to etiology. Many metals have the potential to be neurotoxic, and their exposures are widespread. The field of metals exposure and ASD research is emerging, and in this review article, we assess the current state of the literature, with emphasis on the previous 2 years. Epidemiology studies are discussed with respect to exposure timing, exposure matrix, and outcome assessment. Toxicology studies are described for exposure dosing and timing, as well as behavioral and molecular outcomes. Further epidemiological and toxicological investigations can identify the timing and importance of metals as ASD risk factors and uncover biological mechanisms for risk mitigation and therapeutic strategies.
引用
收藏
页码:39 / 48
页数:10
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