The parathyroid hormone-related protein

被引：24
|
作者：
Strewler, GJ
机构：
[1] Harvard Univ, Sch Med, Dept Med, Boston, MA USA
[2] Vet Adm Boston Healthcare Syst, Dept Med, W Roxbury, MA USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2000年 / 29卷 / 03期
关键词：
D O I：
10.1016/S0889-8529(05)70154-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This article focuses on recent studies that add several new types of cancer to the range of tumors that have parathyroid hormone-related protein (PTHrP) as part of their repertoire. Topics include a new modus operandi for PTHrP as a mediator of local osteolysis around bone metastases, and tentative conclusions on the approach to using assays for PTHrP to aid in the differential diagnosis of hypercalcemia. PTHrP is vital to the normal functioning of mammals. Its role in adults and as a remarkably versatile regulator of development is apparently more ancient than the role of PTH and certainly more protean in action.
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页码：629 / +
页数：18
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