Novel degradable poly(ethylene glycol) esters for drug delivery

被引：0
|
作者：
Zhao, X
Harris, JM [1 ]
机构：
[1] Univ Alabama, Dept Chem, Huntsville, AL 35899 USA
[2] Univ Alabama, Mat Sci Program, Huntsville, AL 35899 USA
来源：
POLY(ETHYLENE GLYCOL): CHEMISTRY AND BIOLOGICAL APPLICATIONS | 1997年 / 680卷
关键词：
D O I：
暂无
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this chapter we describe two applications of new hydrolytically-degradable PEG derivatives. The first involves synthesis of ester-containing PEGs for preparation of soluble PEG-drug conjugates in which the PEG is attached to the drug via a hydrolytically degradable linkage. The second application involves use of these and related PEGs to prepare degradable PEG hydrogels. Degradation rates can be controlled by variation in molecular structure of the esters and in the degree of branching of the PEGs.
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页码：458 / 472
页数：15
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