Tandem heterocyclization of 2-(azolyl-(azinyl-))anilines as an efficient method for preparation of substituted pyrrolo[1,2-a]azolo-(azino-)[c]quinazolines

被引：4

作者：

Stavytskyi, Viktor ^{[1
]}

Voskoboinik, Oleksii ^{[1
]}

Antypenko, Oleksii ^{[1
]}

Krasovska, Nataliia ^{[1
]}

Shabelnyk, Konstantyn ^{[1
]}

Konovalova, Iryna ^{[2
]}

Shishkyna, Svitlana ^{[2
]}

Kholodniak, Sergiy ^{[1
]}

Kovalenko, Serhii ^{[1
]}

机构：

[1] Zaporizhzhia State Med Univ, Dept Organ & Bioorgan Chem, UA-69035 Zaporizhzhia, Ukraine

[2] Natl Acad Sci Ukraine, SSI Inst Single Crystals, Kharkov, Ukraine

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 03期

关键词：

D O I：

10.1002/jhet.3862

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of novel pyrrolo[1,2-a]azolo-(azino-)[c]quinazolines by tandem reaction of 2-(azolyl-(azinyl-))anilines with oxocarboxylic acids was described in this article. The mechanism of obtained compounds formation was proposed, and the intermediate of the heterocyclization has been isolated and characterized. The IR-, H-1 and C-13 NMR-, chromato-mass spectra of synthesized compounds were studied for estimation of their structure and spectral patterns features. The molecular structure of the obtained compounds was additionally proved by X-ray diffraction method.

引用

页码：1249 / 1260

页数：12