Effects of raloxifene on carotid blood flow resistance and endothelium-dependent vasodilation in postmenopausal women

被引:10
|
作者
Ceresini, G
Marchini, L
Rebecchi, I
Morganti, S
Bertone, L
Montanari, I
Bacchi-Modena, A
Sgarabotto, M
Baldini, M
Denti, L
Ablondi, F
Ceda, GP
Valenti, G
机构
[1] Univ Parma, Dept Internal Med & Biomed Sci, Sect Geriatr, I-43100 Parma, Italy
[2] Univ Parma, Dept Gynecol, I-43100 Parma, Italy
关键词
raloxifene; menopause; carotid arteries; endothelial function;
D O I
10.1016/S0021-9150(02)00420-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Raloxifene is one of the most important selective estrogen receptor modulators currently employed for the treatment of postmenopausal osteoporosis. However, it has also been suggested that this compound affects the vascular system. We evaluated both carotid blood flow resistance and endothelium-dependent vasodilation in 50 healthy postmenopausal women randomly assigned to receive, in a double blind design, either raloxifene (60 mg per day; N = 25 subjects) or placebo (N = 25 subjects) for 4 months. Indices of carotid blood flow resistance, such as the pulsatility index (PI) and resistance index (RI), as well as the flow-mediated brachial artery dilation were measured both at baseline and at the end of treatment. Changes in PI were - 1.86 +/- 2.24 and - 2.15 +/- 2.22% after placebo and raloxifene treatment, respectively, with no significant differences between groups. Changes in RI were - 0.77 +/- 1.72 and -1.81 +/- 1.54% after placebo and raloxifene treatment, respectively, with no significant differences between groups. At the end of the treatment period, the increments in artery diameter measured after the flow stimulus were 10.79 +/- 2.39 and 6.70 +/- 1.23% for placebo and raloxifene, respectively, with no significant differences between groups. These results demonstrate no significant effects of raloxifene on either carotid blood flow resistance or brachial artery flow-mediated dilation in postmenopausal women. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:121 / 127
页数:7
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