Diagnostic Value of Corneal Epithelial and Stromal Thickness Distribution Profiles in Forme Fruste Keratoconus and Subclinical Keratoconus

被引:20
|
作者
Toprak, Ibrahim [1 ,2 ]
Vega, Alfredo [1 ,3 ,4 ]
Alio del Barrio, Jorge L. [1 ,3 ,4 ]
Espla, Elias [3 ]
Cavas, Francisco [5 ]
Alio, Jorge L. [1 ,3 ,4 ]
机构
[1] VISSUM, Dept Res & Dev, Alicante, Spain
[2] Pamukkale Univ, Fac Med, Dept Ophthalmol, Denizli, Turkey
[3] VISSUM, Cornea Cataract & Refract Surg Dept, Alicante, Spain
[4] Miguel Hernandez Univ, Fac Med, Dept Pathol & Surg, Div Ophthalmol, Calle Cabanal 1,Edificio Vissum, Alicante 03016, Spain
[5] Univ Politecn Cartagena, Dept Struct Construct & Graph Express, Cartagena, Spain
关键词
corneal topography; diagnosis; epithelium; forme fruste keratoconus; subclinical keratoconus; OPTICAL COHERENCE TOMOGRAPHY; FELLOW EYES; VIDEOKERATOGRAPHY; ABERRATIONS; PARAMETERS; MACHINE; ARTEMIS; INDEX; OCT;
D O I
10.1097/ICO.0000000000002435
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To assess the diagnostic values of corneal epithelial and stromal thickness distribution characteristics in forme fruste keratoconus (FFKC) and subclinical keratoconus (KC). Methods: This cross-sectional study was conducted at VISSUM Innovation and Miguel Hernandez University, Alicante, Spain. Twenty-seven eyes (27 subjects) with FFKC, 50 eyes (50 subjects) with subclinical KC with a best spectacle corrected distance visual acuity >= 20/20 (Snellen) (grade zero KC according to the Red Tematica de Investigacion Cooperativa en Salud classification), and 66 control eyes (66 subjects) were included. Epithelial and stromal thicknesses and epithelium/stroma (E/S) thickness ratio at center, thinnest point, 5-, and 8-mm circles obtained from the MS-39 device (CSO, Firenze, Italy) were compared among the control, FFKC, and subclinical KC groups. Results: The FFKC group had thinner 8-mm superior-nasal epithelium and higher central E/S ratio compared with the control group (P < 0.05). In the subclinical KC group, the E/S ratios in the 5-mm temporal and superior zones were higher than those in the control group (P < 0.05). The FFKC and subclinical KC groups had thinner stroma compared with the control group (P < 0.05). A two-parameter formula correctly classified 94% of the eyes with subclinical KC and 98.5% of the normals, whereas another three-parameter model had 75% sensitivity and 94.3% specificity for discriminating FFKC from normals. Conclusions: This study identified different epithelial distributional and behavioral patterns in eyes with FFKC and subclinical KC. Eyes with FFKC seem to have increased central E/S ratio and asymmetric superior-nasal epithelial thinning, whereas keratometric and volumetric alterations seem to be more prominent in subclinical KC.
引用
收藏
页码:61 / 72
页数:12
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