In Vivo Visualization of Prostate-Specific Membrane Antigen in Adenoid Cystic Carcinoma of the Salivary Gland

被引：30
|
作者：
Luetje, Susanne [1 ]
Sauerwein, Wolfgang [2 ]
Lauenstein, Thomas [3 ]
Bockisch, Andreas [1 ]
Poeppel, Thorsten D. [1 ]
机构：
[1] Univ Hosp Essen, Clin Nucl Med, Hufelandstr 55, D-45122 Essen, Germany
[2] Univ Hosp Essen, Dept Radiat Oncol, BNCTeam, Essen, Germany
[3] Univ Hosp Essen, Inst Diagnost & Intervent Radiol & Neuroradiol, Essen, Germany
来源：
CLINICAL NUCLEAR MEDICINE | 2016年 / 41卷 / 06期
关键词：
adenoid cystic carcinoma; prostate-specific membrane antigen; PET/CT; PET/MRI; neovasculature; CELL CARCINOMA; EXPRESSION; NEOVASCULATURE;
D O I：
10.1097/RLU.0000000000001220
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
As the prostate-specific membrane antigen (PSMA) is overexpressed in the neovasculature of several malignancies, it might serve as a target in oncology. Ga-68-PSMA PET/CT and PET/MRI were performed in a female who developed pulmonary metastases from an adenoid cystic carcinoma of the right sublingual salivary gland after incomplete resection of the primary tumor and radiotherapy. Uptake of Ga-68-PSMA in tumors was observed, indicating PSMA expression. Moreover, a new cerebral metastasis was detected. Potentially, Ga-68-PSMA PET might be used for noninvasive assessment of adenoid cystic carcinoma to evaluate whether patients apply for PSMA-based radiotherapy when no further treatment options are available.
引用
收藏
页码：476 / 477
页数：2
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