Azalomycin F4a 2-ethylpentyl ester, a new macrocyclic lactone, from mangrove actinomycete Streptomyces sp 211726

被引：8
|
作者：
Yuan, Gan Jun [1 ,2 ]
Hong, Kui [1 ]
Lin, Hai Peng [1 ]
Li, Jia [3 ]
机构：
[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
[2] Hainan Med Coll, Dept Pharm, Haikou 571101, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Streptomyces sp 211726; Azalomycin F-4a 2-ethylpentyl ester; Antifungal activity; Cytotoxity;
D O I：
10.1016/j.cclet.2010.03.025
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Azalomycin F-4a 2-ethylpentyl ester, a new 36-membered macrocyclic lactone antibiotic, was isolated from mangrove actinomycete Streptomyces sp. 211726. Its structure was elucidated on the basis of spectroscopic data. The compound showed broad-spectrum antifungal activity and moderate cytotoxicity against human colon tumor cell HCT-116. (C) 2010 Kui Hong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：947 / 950
页数：4
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