Genome-wide association studies of suicidal behaviors: A review

被引:33
|
作者
Sokolowski, Marcus [1 ]
Wasserman, Jerzy [1 ]
Wasserman, Danuta [1 ]
机构
[1] Karolinska Inst, Natl Ctr Suicide Res & Prevent Mental Ill Hlth NA, S-17177 Stockholm, Sweden
关键词
Suicide attempt; GWAS; SNP; Gene; Pathway; Network; MAJOR PSYCHIATRIC-DISORDERS; LOW-FREQUENCY; ANTIDEPRESSANT TREATMENT; CITALOPRAM TREATMENT; SEQUENCE VARIANTS; PATHWAY ANALYSIS; COMMON VARIANTS; CANDIDATE GENES; IDEATION; RISK;
D O I
10.1016/j.euroneuro.2014.08.006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Suicidal behaviors represent a fatal dimension of mental ill-health, involving both environmental and heritable (genetic) influences. The putative genetic components of suicidal behaviors have until recent years been mainly investigated by hypothesis-driven research (of "candidate genes"). But technological progress in genotyping has opened the possibilities towards (hypothesis-generating) genomic screens and novel opportunities to explore polygenetic perspectives, now spanning a wide array of possible analyses falling under the term Genome-Wide Association Study (GWAS). Here we introduce and discuss broadly some apparent limitations but also certain developing opportunities of GWAS. We summarize the results from all the eight GWAS conducted up to date focused on suicidality outcomes; treatment emergent suicidal ideation (3 studies), suicide attempts (4 studies) and completed suicides (1 study). Clearly, there are few (if any) genome-wide significant and reproducible findings yet to be demonstrated. We then discuss and pinpoint certain future considerations in relation to sample sizes, the units of genetic associations used, study designs and outcome definitions, psychiatric diagnoses or biological measures, as well as the use of genomic sequencing. We conclude that GWAS should have a lot more potential to show in the case of suicidal outcomes, than what has yet been realized. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.
引用
收藏
页码:1567 / 1577
页数:11
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