Niacin selectively inhibits hepatocyte DGAT2 but not DGAT1, key enzymes for triglyceride synthesis

被引:0
|
作者
Ganji, SH [1 ]
Xing, YD [1 ]
Kamanna, VS [1 ]
Kashyap, ML [1 ]
机构
[1] VA Healthcare Syst, Long Beach, CA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P249
引用
收藏
页码:A44 / A44
页数:1
相关论文
共 50 条
  • [1] The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes
    Chitraju, Chandramohan
    Walther, Tobias C.
    Farese, Robert V.
    [J]. JOURNAL OF LIPID RESEARCH, 2019, 60 (06) : 1112 - 1120
  • [2] Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells
    Ganji, SH
    Tavintharan, S
    Zhu, DM
    Xing, YD
    Kamanna, VS
    Kashyap, ML
    [J]. JOURNAL OF LIPID RESEARCH, 2004, 45 (10) : 1835 - 1845
  • [3] DGAT1 AND DGAT2 POLYMORPHISMS HAD NO EFFECT ON THE LIPID RESPONSES TO NIACIN IN CHINESE PATIENTS WITH DYSLIPIDAEMIA
    Hu, M.
    Yang, Y.
    Ng, C.
    Lee, C.
    Lee, V.
    Tomlinson, B.
    [J]. ATHEROSCLEROSIS, 2014, 235 (02) : E256 - E256
  • [4] Dictyostelium discoideum Dgat2 Can Substitute for the Essential Function of Dgat1 in Triglyceride Production but Not in Ether Lipid Synthesis
    Du, Xiaoli
    Herrfurth, Cornelia
    Gottlieb, Thomas
    Kawelke, Steffen
    Feussner, Kristin
    Ruehling, Harald
    Feussner, Ivo
    Maniak, Markus
    [J]. EUKARYOTIC CELL, 2014, 13 (04) : 517 - 526
  • [5] Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production
    Millar, John S.
    Stone, Scot J.
    Tietge, Uwe J. F.
    Tow, Bryan
    Billheimer, Jeffrey T.
    Wong, Jinny S.
    Hamilton, Robert L.
    Farese, Robert V., Jr.
    Rader, Daniel J.
    [J]. JOURNAL OF LIPID RESEARCH, 2006, 47 (10) : 2297 - 2305
  • [6] The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications
    Deng, Boer
    Kong, Weimin
    Shen, Xiaochang
    Han, Chao
    Zhao, Ziyi
    Chen, Shuning
    Zhou, Chunxiao
    Bae-Jump, Victoria
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2024, 22 (01)
  • [7] Characterisation of DGAT1 and DGAT2 from Jatropha curcas and their functions in storage lipid biosynthesis
    Xu, Ronghua
    Yang, Tianquan
    Wang, Ruling
    Liu, Aizhong
    [J]. FUNCTIONAL PLANT BIOLOGY, 2014, 41 (03) : 321 - 329
  • [8] The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications
    Boer Deng
    Weimin Kong
    Xiaochang Shen
    Chao Han
    Ziyi Zhao
    Shuning Chen
    Chunxiao Zhou
    Victoria Bae-Jump
    [J]. Journal of Translational Medicine, 22
  • [9] Potential role of DGAT2, but not DGAT1, as,a molecular link between leptin resistance and adipocyte hypertrophy
    Tobe, K
    Suzuki, R
    Inoue, A
    Uchida, S
    Aoyama, M
    Kowatari, N
    Kubota, N
    Terauchi, Y
    Yamauchi, T
    Kadowaki, T
    [J]. DIABETES, 2003, 52 : A2 - A2
  • [10] Niacin inhibits activity of diacyglycerol acyltransferase (DGAT), a key enzyme for triglyceride synthesis, in HepG2 cells
    Zhu, D
    Kamanna, VS
    Kashyap, ML
    [J]. FASEB JOURNAL, 2000, 14 (04): : A430 - A430