Why do we need to regulate autophagy (and how can we do it)? A cartoon depiction

被引:9
|
作者
Klionsky, Daniel J. [1 ]
机构
[1] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
关键词
Autophagosome; frequency; macroautophagy; number; regulation; size;
D O I
10.1080/15548627.2018.1511218
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In a recent issue of this journal I attempted to explain the purpose of macroautophagy/autophagy to a non-specialist audience through the use of cartoons. In the present article, I am continuing this approach by considering the topic of autophagy regulation-why does the cell need to modulate the autophagic response, and what are the basic morphological mechanisms that can be used to attain different levels of autophagy activity?
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页码:1661 / 1664
页数:4
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