A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease

被引：0
|
作者：
Zamolodchikov, Daria [1 ]
Strickland, Sidney [1 ]
机构：
[1] Rockefeller Univ, Lab Neurobiol & Genet, New York, NY 10065 USA
来源：
THROMBOSIS RESEARCH | 2016年 / 141卷
关键词：
Alzheimer's disease; beta-amyloid; fibrin(ogen); factor XII; contact activation system; FACTOR-XII; ANTICOAGULANT-THERAPY; AMYLOID HYPOTHESIS; CONTACT SYSTEM; MOUSE MODEL; FIBRINOGEN; PLASMA; BRAIN; ACTIVATION; DEMENTIA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Alzheimer's disease (AD) is often characterized by vascular pathology, a procoagulant state, and chronic inflammation. The mechanisms behind these abnormalities in AD are not clear. Here, we review evidence for the role of the AD-associated peptide A beta in promoting inflammation and thrombosis in AD via its interaction with the circulating proteins factor XII and fibrinogen. (C) 2016 Elsevier Ltd. All rights reserved.
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收藏
页码：S59 / S61
页数：3
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