Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation

被引：37
|
作者：
Sun, Yating [1 ]
Zhao, Yarong [1 ]
Zhao, Xiuting [1 ]
Lee, Robert J. [1 ,2 ]
Teng, Lesheng [1 ]
Zhou, Chenguang [3 ]
机构：
[1] Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China
[2] Ohio State Univ, Coll Pharm, 500 W 12Th Ave, Columbus, OH 43210 USA
[3] Tavistock Life Sci, San Diego, CA 92130 USA
来源：
MOLECULES | 2017年 / 22卷 / 10期
关键词：
oligonucleotide; siRNA; miRNA; antisense; nanocarriers; TYROSINE KINASE INHIBITOR; SIRNA DELIVERY; IN-VITRO; ANTISENSE OLIGONUCLEOTIDES; CO-DELIVERY; POLYMERIC NANOPARTICLES; INTRACELLULAR DELIVERY; LOADED NANOBUBBLES; GOLD NANOPARTICLES; TARGETED DELIVERY;
D O I：
10.3390/molecules22101724
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer a potential solution to improve the stability and efficacy of ON drugs. Combined with nanoparticle encapsulation, delivery at the site of action and gene silencing activity of chemically modified ON drugs can be further enhanced. In the present review, several types of ON drugs, selection of chemical modification, and nanoparticle-based delivery systems to deliver these ON drugs are discussed.
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页数：26
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