High-frequency oscillation and surfactant treatment in an acid aspiration model

被引:10
|
作者
Aspros, Alexander J. [1 ,2 ]
Coto, Claudia G. [1 ,2 ]
Lewis, James F. [1 ,2 ,3 ]
Veldhuizen, Ruud A. W. [1 ,2 ,3 ]
机构
[1] Univ Western Ontario, Lawson Hlth Res Inst, London, ON N6A 4V2, Canada
[2] Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 4V2, Canada
[3] Univ Western Ontario, Dept Med, London, ON N6A 4V2, Canada
关键词
acid aspiration; conventional mechanical ventilation; high-frequency oscillatory ventilation; lung injury; mechanical; ventilation; surfactant therapy; ACUTE LUNG INJURY; RESPIRATORY-DISTRESS-SYNDROME; EXOGENOUS SURFACTANT; MECHANICAL VENTILATION; AGGREGATE CONVERSION; PULMONARY SURFACTANT; RABBIT MODEL; STRATEGIES; PNEUMONIA; THERAPY;
D O I
10.1139/Y09-096
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Both exogenous surfactant therapy and high-frequency oscillation (HFO) have been proposed as clinical interventions in acute respiratory distress syndrome (ARDS). The combination of these 2 interventions has not been studied in a relevant model of ARDS. It was hypothesized that surfactant treatment combined with HFO is superior to either surfactant treatment or HFO alone in a model of ARDS. Adult rats had lung injury induced by instillation of 0.1 mol/L HCL followed by randomization to one of 4 groups: Conventional mechanical ventilation (CMV)+air (no treatment), CMV+surfactant, HFO+air, and HFO+surfactant. Oxygenation, lung compliance, surfactant, and cytokine concentrations in the lung lavage were analyzed. The results showed superior oxygenation in HFO ventilated animals regardless of surfactant treatment compared with CMV. Nonsurfactant-treated animals ventilated with HFO had a significantly greater proportion of large aggregates, and had greater lung compliance compared with non-surfactant-treated animals ventilated with CMV. Surfactant therapy combined with HFO provided no advantages with respect to these outcomes. These data suggest an advantage of HFO over CMV when exogenous surfactant was not given, and that surfactant treatment combined with HFO was not superior to HFO ventilation alone.
引用
收藏
页码:14 / 20
页数:7
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