Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery

被引：51
|
作者：
Huang, Ya [1 ,2 ]
Li, Hu [1 ]
Hu, Tianli [1 ]
Li, Jian [1 ,2 ]
Yiu, Chun Ki [1 ,2 ]
Zhou, Jingkun [1 ,2 ]
Li, Jiyu [1 ,2 ]
Huang, Xingcan [1 ]
Yao, Kuanming [1 ]
Qiu, Xiao [4 ]
Zhou, Yu [4 ]
Li, Dengfeng [1 ,2 ]
Zhang, Binbin [1 ]
Shi, Rui [1 ]
Liu, Yiming [1 ]
Wong, Tsz Hung [1 ]
Wu, Mengge [1 ]
Jia, Huiling [1 ]
Gao, Zhan [1 ]
Zhang, Zhibiao [1 ]
He, Jiahui [1 ]
Zheng, Mengjia [1 ]
Song, Enming [5 ]
Wang, Lidai [1 ,3 ]
Xu, Chenjie [1 ]
Yu, Xinge [1 ,2 ,3 ]
机构：
[1] City Univ Hong Kong, Dept Biomed Engn, Hong Kong 999077, Peoples R China
[2] Hong Kong Ctr Cerebro Cardiovasc Hlth Engn, Hong Kong 999077, Peoples R China
[3] City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Peoples R China
[4] Hong Kong Univ Sci & Technol, Dept Elect & Comp Engn, Hong Kong 999077, Peoples R China
[5] Fudan Univ, Inst Optoelect, Shanghai Frontiers Sci Res Base Intelligent Optoel, Shanghai 200433, Peoples R China
来源：
NANO LETTERS | 2022年 / 22卷 / 14期
基金：
中国国家自然科学基金;
关键词：
electronic medicine; implantable electronics; microneedle; drug delivery; electrostimulation; ELECTRICAL-STIMULATION; TRANSIENT; DIFFERENTIATION; CORROSION; METALS; GOLD;
D O I：
10.1021/acs.nanolett.2c01997
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A combined treatment using medication and electro-stimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorb-able microneedle devices that is activated wirelessly for electro-stimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal.
引用
收藏
页码：5944 / 5953
页数：10
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  • [1] Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants
    Lee, Chi Hwan
    Kim, Hojun
    Harburg, Daniel V.
    Park, Gayoung
    Ma, Yinji
    Pan, Taisong
    Kim, Jae Soon
    Lee, Na Yeon
    Kim, Bong Hoon
    Jang, Kyung-In
    Kang, Seung-Kyun
    Huang, Yonggang
    Kim, Jeongmin
    Lee, Kyung-Mi
    Leal, Cecilia
    Rogers, John A.
    [J]. NPG ASIA MATERIALS, 2015, 7 : e227 - e227
  • [2] Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants
    Chi Hwan Lee
    Hojun Kim
    Daniel V Harburg
    Gayoung Park
    Yinji Ma
    Taisong Pan
    Jae Soon Kim
    Na Yeon Lee
    Bong Hoon Kim
    Kyung-In Jang
    Seung-Kyun Kang
    Yonggang Huang
    Jeongmin Kim
    Kyung-Mi Lee
    Cecilia Leal
    John A Rogers
    [J]. NPG Asia Materials, 2015, 7 : e227 - e227
  • [3] A Wireless Implantable Potentiostat for Programmable Electrochemical Drug Delivery
    Wang, Max L.
    Yeon, Pyungwoo
    Chamberlayne, Christian F.
    Mofidfar, Mohammad
    Xu, Haixia
    Annes, Justin P.
    Zare, Richard N.
    Arbabian, Amin
    [J]. 2021 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (IEEE BIOCAS 2021), 2021,
  • [4] Soft, Long-Lived, Bioresorbable Electronic Surgical Mesh with Wireless Pressure Monitor and On-Demand Drug Delivery
    Kaveti, Rajaram
    Lee, Joong Hoon
    Youn, Joong Kee
    Jang, Tae-Min
    Han, Won Bae
    Yang, Seung Min
    Shin, Jeong-Woong
    Ko, Gwan-Jin
    Kim, Dong-Je
    Han, Sungkeun
    Kang, Heeseok
    Bandodkar, Amay J.
    Kim, Hyun-Young
    Hwang, Suk-Won
    [J]. ADVANCED MATERIALS, 2024, 36 (11)
  • [5] Wireless Shape Memory Polymer Microactuator for Implantable Drug Delivery Aplication
    Zainal, M. A.
    Ali, M. S. Mohamed
    [J]. 2016 IEEE EMBS CONFERENCE ON BIOMEDICAL ENGINEERING AND SCIENCES (IECBES), 2016, : 76 - 79
  • [6] Novel Aspects of Drug Delivery: Wireless Electronic Devices
    Tatlic, Berina
    Sejto, Lejla
    Sirbubalo, Merima
    Tucak, Amina
    Vranic, Edina
    [J]. PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON MEDICAL AND BIOLOGICAL ENGINEERING, CMBEBIH 2019, 2020, 73 : 547 - 551
  • [7] Implantable small device enabled with magnetic actuation for on-demand and pulsatile drug delivery
    Lee, Seung Ho
    Kim, Byung Hwi
    Park, Chun Gwon
    Lee, Cheol
    Lim, Byung Yoon
    Choy, Young Bin
    [J]. JOURNAL OF CONTROLLED RELEASE, 2018, 286 : 224 - 230
  • [8] Implementation of wireless power transfer and communications for an implantable ocular drug delivery system
    Tang, T. B.
    Smith, S.
    Flynn, B. W.
    Stevenson, J. T. M.
    Gundlach, A. M.
    Reekie, H. M.
    Murray, A. F.
    Renshaw, D.
    Dhillon, B.
    Ohtori, A.
    Inoue, Y.
    Terry, J. G.
    Walton, A. J.
    [J]. IET NANOBIOTECHNOLOGY, 2008, 2 (03) : 72 - 79
  • [9] Implantable drug delivery device using frequency-controlled wireless hydrogel microvalves
    Somayyeh Rahimi
    Elie H. Sarraf
    Gregory K. Wong
    Kenichi Takahata
    [J]. Biomedical Microdevices, 2011, 13 : 267 - 277
  • [10] Implantable drug delivery device using frequency-controlled wireless hydrogel microvalves
    Rahimi, Somayyeh
    Sarraf, Elie H.
    Wong, Gregory K.
    Takahata, Kenichi
    [J]. BIOMEDICAL MICRODEVICES, 2011, 13 (02) : 267 - 277
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