Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation

被引：18
|
作者：
Zhu, Zhou [1 ]
Oh, Sun Young [1 ]
Cho, You Sook [1 ]
Zhang, Li [1 ]
Kim, Yoon-Keun [1 ]
Zheng, Tao [1 ]
机构：
[1] Johns Hopkins Univ, Johns Hopkins Asthma & Allergy Ctr, Div Clin Immunol & Allergy, Baltimore, MD 21224 USA
来源：
IMMUNOLOGIC RESEARCH | 2010年 / 47卷 / 1-3期
关键词：
Phosphatase; Mast cells; Th2; cytokines; Allergic inflammatory response; Allergy; Asthma; HEMATOPOIETIC-CELL PHOSPHATASE; N-TERMINAL KINASE; MOTH-EATEN MICE; FC-GAMMA-RIIB; MAST-CELLS; NEGATIVE REGULATION; HISTAMINE-RELEASE; OXIDATIVE STRESS; GENE-EXPRESSION; HUMAN BASOPHILS;
D O I：
10.1007/s12026-009-8134-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.
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收藏
页码：3 / 13
页数：11
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