A comparison of placebo response with major depressive disorder in patients recruited through newspaper advertising versus consultation referrals

被引:0
|
作者
Miller, CA
Hooper, CL
Bakish, D
机构
[1] Royal Ottawa Hosp, Psychopharmacol Unit, Ottawa, ON K1Z 7K4, Canada
[2] Royal Ottawa Hosp, Mental Hlth Res Inst, Ottawa, ON K1Z 7K4, Canada
[3] Univ Ottawa, Dept Psychiat, Ottawa, ON K1N 6N5, Canada
关键词
placebo effect; clinical trial; double-blind; patient selection; depressive disorder;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recent evidence indicates few differences between patients recruited through advertising and by consultation referral, and there is some suggestion that those recruited through advertising are more representative of the target community population. However little has been reported on differences in placebo response and compliance In these two patient groups. We conducted a retrospective chart review of 49 patients with major depressive disorder (MDD), recruited through advertising or consultation, randomized to placebo in five clinical trials. Variables included demographics, clinical history, efficacy, compliance, and completion data. Homogeneity was demonstrated for most variables. Differences in placebo groups included significantly lower Hamilton Rating Scale for Depression (HAM-D) scores for the advertisement group throughout the trials. Advertisement patients were also more likely to be early placebo responders and in remission at Days 14 and 28. No differences were found in completion rates or reasons for early termination. Compliance was excellent for both groups. Early placebo response of the advertisement group reinforces the need for trials of at least 8 weeks. In addition, consultation patients may have a more severe illness and be treatment resistant, suggesting they are less generalizable to community practice populations.
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页码:647 / 651
页数:5
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