Oxidative Trimerization of Amino Acids: Selective Synthesis of 2,3,5-Trisubstituted Pyridines

被引：19

作者：

Xiang, Jia-Chen ^{[1
]}

Cheng, Yan ^{[1
]}

Wang, Zi-Xuan ^{[1
]}

Ma, Jin-Tian ^{[1
]}

Wang, Miao ^{[1
]}

Tang, Bo-Cheng ^{[1
]}

Wu, Yan-Dong ^{[1
]}

Wu, An-Xin ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 11期

基金：

中国国家自然科学基金;

关键词：

BOND ACTIVATION; DERIVATIVES; ALDEHYDES; ACETATES; ORIGIN; ALKYNE; ESTERS;

D O I：

10.1021/acs.orglett.7b01232

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An oxidative trimerization of three amino acids has been realized to furnish 2,3,5-trisubstuitued pyridines in both cross- and homo-trimerization types. This method is capable of converting simple linear biomass material to heterocycles, which features in the assembly of three amino acid branched chains into one aromatic ring. Molecular iodine triggers the sequential decarboxylation and deamination of amino acids and then promotes the selective formation of new C-N and C-C bonds.

引用

页码：2997 / 3000

页数：4

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