Neural differentiation of mouse embryonic stem cells

被引：70
|
作者：
Stavridis, MP [1 ]
Smith, AG [1 ]
机构：
[1] Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷
关键词：
in vitro neurogenesis; neuron; neural progenitor;
D O I：
10.1042/bst0310045
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pluripotent embryonic stem cells can give rise to neuroectodermal derivatives in culture. This potential could be harnessed to generate neurons and glia for cell-replacement therapies in the central nervous system and for use in drug discovery. However, current methods of neural differentiation are empirical and relatively innefficient. Here, we review these methodologies and present new tools for quantification, analysis and manipulation of embryonic stem cell neural determination.
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收藏
页码：45 / 49
页数：5
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