Synthesis of 2,3-Ring Fused Pyrroles via Cu-Catalyzed 5-exo-dig Annulation of Alkyne-Tethered Enaminones

被引：9

作者：

Li, Weishuang ^{[1
,2
]}

Usman, Muhammad ^{[1
,2
]}

Wu, Lin-Yang ^{[1
,2
]}

Liu, Wen-Bo ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat, Minist Educ, Wuhan 430072, Hubei, Peoples R China

[2] Wuhan Univ, Sauvage Ctr Mol Sci, Wuhan 430072, Hubei, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 23期

关键词：

POLYSUBSTITUTED PYRROLES; EFFICIENT SYNTHESIS; CYCLIZATION; HYDROAMINATION; DERIVATIVES; AMINES; INDOLES;

D O I：

10.1021/acs.joc.9b02672

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed annulation of alkyne-tethered enaminones for the synthesis of 2,3-ring fused pyrroles is reported. The S-exo-dig cyclization/olefin migration reaction delivers the multisubstituted pyrroles in 59-99% yields with 16 examples. This strategy features easily available starting materials, mild reaction conditions, and a cheap ligand-free copper catalyst. The atom-economic transformation provides a simple access to a variety of synthetic useful pyrroles and their derivatives.

引用

页码：15754 / 15763

页数：10

共 13 条

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