Neopterin and alt as markers of inflammation in chronic hepatitis C patients during administration of the HCVNS3-4a protease inhibitor telaprevir (VX-950) in combination with peginterferon ALFA 2a

被引：3
|
作者：
Gelderblom, H. C.
Zeuzem, S.
Weegink, C. J.
Forestier, N.
McNair, L.
Purdy, S.
Jansen, P. L. M.
Reesink, H. W.
机构：
[1] Univ Amsterdam, Acad Med Ctr, AMC Liver Ctr, Dept Gastroenterol & Hepatol, NL-1105 AZ Amsterdam, Netherlands
[2] Saarland Univ Hosp, Homburg, Germany
[3] Vertex Pharmaceut Inc, Cambridge, MA USA
来源：
JOURNAL OF HEPATOLOGY | 2007年 / 46卷
关键词：
D O I：
10.1016/S0168-8278(07)62190-4
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
592
引用
收藏
页码：S224 / S225
页数：2
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  • [1] Inflammatory markers neopterin and alanine aminotransferase in HCV patients treated with HCVNS3•4A protease inhibitor telaprevir (VX-950) and/or peginterferon alfa-2a
    Gelderblom, Huub C.
    Zeuzem, Stefan
    Weegink, Christine J.
    Forestier, Nicole
    Mcnair, Lindsay
    Purdy, Susan
    Dijkgraaf, Marcel G. W.
    Jansen, Peter L. M.
    Reesink, Henk W.
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2008, 43 (09) : 1122 - 1127
  • [2] Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C
    Forestier, Nicole
    Reesink, Hendrik W.
    Weegink, Christine J.
    McNair, Lindsay
    Kieffer, Tara L.
    Chu, Hui-May
    Purdy, Susan
    Jansen, Peter L. M.
    Zeuzem, Stefan
    [J]. HEPATOLOGY, 2007, 46 (03) : 640 - 648
  • [3] Ultrasound evaluation of perihepatic lymph nodes during antiviral therapy with the protease inhibitor telaprevir (VX-950) in patients with chronic hepatitis C infection
    Friedrich-Rust, M.
    Forestier, N.
    Sarrazin, C.
    Reesink, H. W.
    Herrmann, E.
    Zeuzem, S.
    [J]. JOURNAL OF HEPATOLOGY, 2007, 46 : S205 - S205
  • [4] Ultrasound evaluation of perihepatic lymph nodes during antiviral therapy with the protease inhibitor telaprevir (VX-950) in patients with chronic hepatitis c infection
    Friedrich-Rust, Mirfen
    Forestier, Nicole
    Sarrazin, Christoph
    Reesink, Henk W.
    Herrmann, Eva
    Zeuzem, Stefan
    [J]. ULTRASOUND IN MEDICINE AND BIOLOGY, 2007, 33 (09): : 1362 - 1367
  • [5] Decline in serum neopterin concentration correlates with HCV RNA decline during administration of VX-950, a hepatitis C virus protease inhibitor
    Gelderblom, HC
    Zeuzem, S
    Weegink, CJ
    Forestier, N
    McNair, L
    Purdy, S
    Jansen, PL
    Reesink, HW
    [J]. HEPATOLOGY, 2005, 42 (04) : 533A - 534A
  • [6] Viral dynamics study with HCVNS3-4A protease inhibitor MP-424/VX-950 in human-chimeric liver mouse model for hepatitis C virus infection
    Kamiya, Naohiro
    Iwao, Eiji
    Hiraga, Nobuhiko
    Imamura, Michio
    Takahashi, Shoichi
    Chayama, Kazuaki
    [J]. HEPATOLOGY, 2006, 44 (04) : 535A - 535A
  • [7] Initial results of a 14-day study of the hepatitis C virus inhibitor protease VX-950, in combination with peginterferon-alpha-2a
    Reesink, H. W.
    Forestier, N.
    Weegink, C. J.
    Zeuzem, S.
    McNair, L.
    Purdy, S.
    Chu, H. -M.
    Jansen, P. L. M.
    [J]. JOURNAL OF HEPATOLOGY, 2006, 44 : S272 - S272
  • [8] Tolerability and antiviral effects in a 28-day study of the hepatitis C protease inhibitor Telaprevir (VX-950), in combination with peg-interforon-alpha-2a and ribavirin
    Lawitz, E.
    Rodriguez-Torres, M.
    Muir, A.
    Keane, J.
    Kieffer, T.
    McNair, L.
    McHutchison, J.
    [J]. JOURNAL OF CLINICAL VIROLOGY, 2006, 36 : S239 - S239
  • [9] 28 days of the hepatitis C protease inhibitor VX-950, in combination with PEG-interferon-ALFA-2a and ribavirin, is well-tolerated and demonstrates robust antiviral effects
    Lawitz, E. J.
    Rodriguez-Torres, M.
    Muir, A.
    Keane, J.
    Kieffer, T.
    McNair, L.
    McHutchison, J. G.
    [J]. GASTROENTEROLOGY, 2006, 131 (03) : 950 - 951
  • [10] PROVE2: Phase II study of VX950 (telaprevir) in combination with peginterferon alfa2a with or without ribavirin in subjects with chronic hepatitis C, first interim analysis
    Hezode, Christophe
    Ferenci, Peter
    Dusheiko, Geoffrey M.
    Pol, Stanislas
    Goeser, Tobias
    Bronowicki, Jean-Pierre
    Gharakhanian, Shahin
    Devonish, Desiree
    Kauffman, Robert
    Alam, John
    Pawlotsky, Jean-Michel
    Zeuzem, Stefan
    [J]. HEPATOLOGY, 2007, 46 (04) : 268A - 269A
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